Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473427 | 0.94 | DPP4 (0.46) | HDAC1HDAC6DPP4FABP4MAPT | |
| SCHEMBL7422336 | 0.88 | FABP4 (0.57) | HDAC1HDAC6DPP4FABP4ALDH1A1 | |
| SCHEMBL7428003 | 0.87 | HDAC1 (0.54) | HDAC1HDAC6DPP4FABP4TP53 | |
| SCHEMBL7422984 | 0.86 | DPP4 (0.47) | DPP4FABP4MAPTTP53LMNA | |
| SCHEMBL7470778 | 0.82 | DPP4 (0.46) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7418839 | 0.82 | FABP4 (0.54) | HDAC1HDAC6DPP4FABP4ALDH1A1 | |
| SCHEMBL7414769 | 0.81 | HDAC1 (0.46) | HDAC1HDAC6DPP4FABP4TP53 | |
| SCHEMBL6694051 | 0.80 | HDAC1 (0.44) | HDAC1HDAC6DPP4MAPTTP53 | |
| SCHEMBL14895937 | 0.80 | HDAC6 (0.75) | HDAC1HDAC6PTGS1PTGS2 | |
| SCHEMBL7428023 | 0.76 | MAPT (0.47) | DPP4MAPTTP53LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |