Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.39 |
| ▸ | NSD2 | O96028 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483596 | 0.94 | TBK1 (0.40) | TBK1NSD2EGFRERBB2IKBKE | |
| SCHEMBL7484170 | 0.87 | NSD2 (0.40) | TBK1NSD2IKBKEPDE4BBRD4 | |
| SCHEMBL7484168 | 0.87 | TBK1 (0.40) | TBK1NSD2IKBKEEHMT2PDE4A | |
| SCHEMBL7488290 | 0.87 | TBK1 (0.40) | TBK1NSD2EGFRERBB2IKBKE | |
| SCHEMBL7488801 | 0.85 | PDE4A (0.38) | TBK1NSD2IKBKEDPP4PDE4A | |
| SCHEMBL7477494 | 0.85 | TBK1 (0.42) | TBK1NSD2IKBKEPDE4APDE4B | |
| SCHEMBL7483915 | 0.85 | NSD2 (0.42) | TBK1NSD2IKBKEPDE4APDE4B | |
| SCHEMBL7488680 | 0.85 | TBK1 (0.40) | TBK1NSD2IKBKEEHMT2PDE4A | |
| SCHEMBL7478116 | 0.84 | NSD2 (0.41) | TBK1NSD2IKBKEPDE4APDE4B | |
| SCHEMBL7483999 | 0.84 | NSD2 (0.41) | TBK1NSD2IKBKEPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |