Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.40 |
| ▸ | NSD2 | O96028 | 3/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484168 | 0.97 | TBK1 (0.40) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7483999 | 0.90 | NSD2 (0.41) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7483915 | 0.89 | NSD2 (0.42) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7478116 | 0.89 | NSD2 (0.41) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7477494 | 0.88 | TBK1 (0.42) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7483596 | 0.88 | TBK1 (0.40) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7475851 | 0.88 | TBK1 (0.40) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7481361 | 0.87 | TBK1 (0.41) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7484173 | 0.87 | TBK1 (0.41) | TBK1NSD2IKBKEPDE4BPDE4A | |
| SCHEMBL7475002 | 0.87 | TBK1 (0.39) | TBK1NSD2IKBKEPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |