SCHEMBL7475070

SCHEMBL7475070

FC(F)(F)c1cccc2c1CN(Nc1ccncc1)C2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 1/20 0.41
NAMPT P43490 1/20 0.40
NISCH Q9Y2I1 1/20 0.38
TRPV1 Q8NER1 1/20 0.38
TEAD1 P28347 2/20 0.37
TEAD4 Q15561 2/20 0.37
TEAD2 Q15562 2/20 0.37
PHGDH O43175 2/20 0.36
KMT2A Q03164 3/20 0.35
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7480722 0.80 CYP19A1 (0.41) NISCHCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7484317 0.78 NISCH (0.40) TYK2NISCHKMT2AMEN1LMNA
Bromide SCHEMBL7478970 0.78 CYP19A1 (0.40) NISCHCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7484163 0.78 NISCH (0.40) NISCHSLC6A2
SCHEMBL7481285 0.77 SLC6A2 (0.47) TYK2NAMPTNISCHSLC6A2
Hydrochloric Acid SCHEMBL7482061 0.75 SLC6A2 (0.46) TYK2NAMPTSLC6A2
SCHEMBL7480365 0.75 CYP19A1 (0.44) NISCHALDH1A1DRD2
SCHEMBL27510912 0.73 NISCH (0.34) NISCHTEAD1TEAD4TEAD2PHGDH
SCHEMBL7477144 0.70 NISCH (0.31) NISCHKMT2AMEN1SLC6A2
SCHEMBL7479374 0.69 CYP19A1 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
CN-1242012-A N- (pyridylamino) isoindolines and related compounds HOECHST MARION ROUSSEL INC (US) 2000-01-19 CN disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed