Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480722 | 0.83 | CYP19A1 (0.41) | NISCHSLC6A2 | |
| SCHEMBL7484317 | 0.82 | NISCH (0.40) | NISCHSLC6A2CDK5CDK5R1TRAP1 | |
| Bromide SCHEMBL7478970 | 0.82 | CYP19A1 (0.40) | NISCHSLC6A2 | |
| SCHEMBL7481285 | 0.80 | SLC6A2 (0.47) | NISCHSLC6A2CTSD | |
| Hydrochloric Acid SCHEMBL7482061 | 0.79 | SLC6A2 (0.46) | SLC6A2CTSD | |
| SCHEMBL7475070 | 0.78 | TYK2 (0.41) | NISCHSLC6A2 | |
| SCHEMBL7480365 | 0.78 | CYP19A1 (0.44) | NISCHABHD6 | |
| SCHEMBL7479374 | 0.72 | CYP19A1 (0.41) | — | |
| SCHEMBL7483738 | 0.72 | ACHE (0.40) | NISCH | |
| SCHEMBL8586063 | 0.72 | NISCH (0.36) | NISCHSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| CN-1242012-A | N- (pyridylamino) isoindolines and related compounds | HOECHST MARION ROUSSEL INC (US) | 2000-01-19 | — | — | CN | claimed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | claimed |