SCHEMBL7475159

SCHEMBL7475159

CCOc1cc2c(cc1OCC)[C@H](c1ccccc1)N[C@@](CC)(CC(O)CC(F)(F)F)CS2

nearest known ligand 0.36

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 20/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7475155 1.00 SLC10A2 (0.36) SLC10A2
SCHEMBL7473807 0.92 SLC10A2 (0.42) SLC10A2
SCHEMBL7473804 0.92 SLC10A2 (0.42) SLC10A2
SCHEMBL7477854 0.92 SLC10A2 (0.38) SLC10A2
SCHEMBL7477850 0.92 SLC10A2 (0.38) SLC10A2
SCHEMBL7474830 0.87 SLC10A2 (0.32) SLC10A2
SCHEMBL7474825 0.87 SLC10A2 (0.32) SLC10A2
SCHEMBL7479121 0.85 SLC10A2 (0.36) SLC10A2
SCHEMBL7484164 0.85 MEN1 (0.38) SLC10A2
SCHEMBL7484166 0.85 MEN1 (0.38) SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723458-A 1,4-BENZOTHIAZEPINES GLAXO WELLCOME INC. (US) 1998-03-03 US claimed
WO-1994018184-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1994-08-18 WO claimed
EP-0683774-B1 HYPOLIPIDAEMIC COMPOUNDS WELLCOME FOUND (GB) 2002-10-09 EP disclosed
EP-0971744-A2 COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 2000-01-19 EP disclosed
WO-1998040375-A2 COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 1998-09-17 WO disclosed
US-5723458-A 1,4-BENZOTHIAZEPINES GLAXO WELLCOME INC. (US) 1998-03-03 US disclosed
WO-1994018184-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1994-08-18 WO disclosed