SCHEMBL7484164

SCHEMBL7484164

COc1cc2c(cc1OC)C(c1ccccc1)NC(CC(O)CC(F)(F)F)(CC(F)(F)F)CS2

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
SLC10A2 Q12908 18/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7484166 1.00 MEN1 (0.38) MEN1KMT2ASLC10A2
SCHEMBL7473804 0.93 SLC10A2 (0.42) MEN1KMT2ASLC10A2
SCHEMBL7473807 0.93 SLC10A2 (0.42) MEN1KMT2ASLC10A2
SCHEMBL7479396 0.88 SLC6A9 (0.33) MEN1KMT2ASLC10A2
SCHEMBL7479400 0.88 SLC6A9 (0.33) MEN1KMT2ASLC10A2
SCHEMBL7475159 0.85 SLC10A2 (0.36) SLC10A2
SCHEMBL7475155 0.85 SLC10A2 (0.36) SLC10A2
SCHEMBL8797690 0.82 SLC10A2 (0.41) MEN1KMT2ASLC10A2
SCHEMBL8689710 0.82 SLC10A2 (0.41) MEN1KMT2ASLC10A2
SCHEMBL9214291 0.82 SLC10A2 (0.41) MEN1KMT2ASLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0683774-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-29 EP claimed
WO-1994018184-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1994-08-18 WO claimed
EP-0683774-B1 HYPOLIPIDAEMIC COMPOUNDS WELLCOME FOUND (GB) 2002-10-09 EP disclosed
US-5723458-A 1,4-BENZOTHIAZEPINES GLAXO WELLCOME INC. (US) 1998-03-03 US disclosed
EP-0683774-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-29 EP disclosed
WO-1994018184-A1 HYPOLIPIDAEMIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1994-08-18 WO disclosed