Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411490 | 0.87 | EGFR (0.60) | EGFR | |
| SCHEMBL28182145 | 0.87 | EGFR (0.51) | EGFREPHA2 | |
| SCHEMBL7459033 | 0.84 | MAPT (0.46) | EGFRMKNK2ALDH1A1LMNAKMT2A | |
| SCHEMBL7473037 | 0.84 | SRC (0.49) | EGFRMEN1USP2ALDH1A1LMNA | |
| SCHEMBL7470018 | 0.84 | USP10 (0.57) | EGFRMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL7461671 | 0.82 | HTT (0.52) | EGFRMEN1LMNAKMT2AOPRL1 | |
| SCHEMBL28181388 | 0.81 | EGFR (0.56) | EGFRMKNK2MKNK1ALDH1A1LMNA | |
| SCHEMBL7470038 | 0.80 | HTT (0.45) | EGFROPRL1HTT | |
| SCHEMBL7473882 | 0.79 | EGFR (0.68) | EGFRMEN1USP2ALDH1A1LMNA | |
| SCHEMBL28397062 | 0.79 | EGFR (0.68) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |