Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 16/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786057 | 0.87 | KDM4E (0.59) | DHODHPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL6842031 | 0.86 | PARP1 (0.66) | DHODHPARP1 | |
| SCHEMBL15808958 | 0.84 | PKN1 (0.62) | DHODHPARP1KDM4EALDH1A1TDP1 | |
| SCHEMBL9725333 | 0.82 | DHODH (0.77) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL7475443 | 0.80 | PARP1 (0.55) | PARP1KDM4EHPGDALDH1A1TDP1 | |
| SCHEMBL1298127 | 0.79 | PARP1 (0.73) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL825449 | 0.78 | KDM4E (0.73) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL6519737 | 0.77 | ALDH1A1 (0.42) | DHODHPARP1KDM4EHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL829317 | 0.77 | KDM4E (0.71) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL7863163 | 0.77 | PARP1 (0.63) | DHODHPARP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |