Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942271 | 0.79 | — | — | |
| SCHEMBL4969556 | 0.79 | ADRA2C (0.33) | — | |
| SCHEMBL4969550 | 0.79 | ADRA2C (0.33) | — | |
| SCHEMBL7464025 | 0.78 | KDM4E (0.33) | — | |
| SCHEMBL7469422 | 0.78 | HRH3 (0.35) | — | |
| SCHEMBL949339 | 0.77 | ADRA2C (0.36) | — | |
| SCHEMBL949544 | 0.74 | HRH3 (0.33) | — | |
| SCHEMBL12359552 | 0.74 | SLC6A2 (0.37) | — | |
| SCHEMBL7477075 | 0.73 | CHKA (0.33) | — | |
| SCHEMBL7475522 | 0.73 | SLC6A2 (0.34) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-B1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-6140330-A | USEFUL AS PROTEIN KINASE INHIBITOR; FOR TREATMENT OF AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, MULTIPLE SCLEROSIS, PSORIASIS, ETC., VARIOUS ALLERGIC DISEASES SUCH AS CROHN'S DISEASE, ASTHMA | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-10-31 | — | — | US | disclosed |