Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.42 |
| ▸ | CDK8 | P49336 | 7/20 | 0.42 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27479238 | 0.83 | NOTUM (0.47) | CCNCCDK8NOTUMKDM4EATAD2 | |
| SCHEMBL20157257 | 0.80 | CCNC (0.51) | CCNCCDK8GDANOTUMPDPK1 | |
| SCHEMBL16883380 | 0.78 | KDM4E (0.40) | NOTUMALDH1A1LMNATSHRKDM4E | |
| Alcohol SCHEMBL27460337 | 0.76 | NOTUM (0.41) | CCNCCDK8NOTUMKDM4E | |
| SCHEMBL2576551 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL7560908 | 0.74 | CCNC (0.50) | CCNCCDK8GDANOTUMPDPK1 | |
| SCHEMBL13790182 | 0.72 | CCNC (0.42) | CCNCCDK8GDAALDH1A1LMNA | |
| SCHEMBL1801972 | 0.70 | NOTUM (0.47) | CCNCCDK8GDANOTUMALDH1A1 | |
| SCHEMBL7116182 | 0.67 | CCNC (0.47) | CCNCCDK8NOTUMALDH1A1KDM4E | |
| SCHEMBL1082611 | 0.67 | NOTUM (0.65) | CCNCCDK8NOTUMALDH1A1SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |