Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.50 |
| ▸ | CDK8 | P49336 | 7/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875350 | 0.83 | KDM4E (0.39) | CCNCCDK8TSHRKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6941254 | 0.81 | KDM4E (0.38) | CCNCCDK8TSHRKDM4EALDH1A1 | |
| SCHEMBL20157257 | 0.80 | CCNC (0.51) | CCNCCDK8PDPK1GDALMNA | |
| SCHEMBL3627973 | 0.78 | ALDH1A1 (0.40) | TSHRKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL3113133 | 0.76 | ALDH1A1 (0.39) | TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL7116182 | 0.75 | CCNC (0.47) | CCNCCDK8KDM4EALDH1A1MEN1 | |
| SCHEMBL7052811 | 0.75 | CYP1A2 (0.49) | LMNAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7475587 | 0.74 | CCNC (0.42) | CCNCCDK8PDPK1GDALMNA | |
| SCHEMBL21362561 | 0.74 | CCNC (0.46) | CCNCCDK8GDAKDM4EALDH1A1 | |
| SCHEMBL30317801 | 0.72 | CCNC (0.45) | CCNCCDK8GDA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |