Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.32 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468291 | 0.82 | NR1H2 (0.38) | DRD2DRD3KCNH2S1PR1TMEM97 | |
| Trifluoroacetic Acid SCHEMBL7480684 | 0.81 | ITGB3 (0.49) | ITGB3ITGA2BITGA2 | |
| SCHEMBL7474006 | 0.81 | ITGB3 (0.38) | DRD2DRD3KCNH2S1PR1HTR6 | |
| SCHEMBL7469768 | 0.78 | MAPT (0.41) | DRD2DRD3KCNH2S1PR1ITGB3 | |
| Trifluoroacetic Acid SCHEMBL7476025 | 0.77 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL7474127 | 0.75 | TMEM97 (0.43) | DRD2DRD3KCNH2S1PR1TMEM97 | |
| SCHEMBL7474864 | 0.74 | TMEM97 (0.39) | DRD2DRD3KCNH2TMEM97SIGMAR1 | |
| SCHEMBL7472620 | 0.74 | ITGB3 (0.49) | S1PR1HTR6ITGB3ITGA2BITGA2 | |
| SCHEMBL7479149 | 0.73 | ITGB3 (0.40) | DRD2DRD3KCNH2S1PR1ITGB3 | |
| Trifluoroacetic Acid SCHEMBL7481102 | 0.73 | ITGB3 (0.48) | ITGB3ITGA2BITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |