Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469768 | 0.90 | MAPT (0.41) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7468291 | 0.90 | NR1H2 (0.38) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7478252 | 0.84 | ITGB3 (0.47) | — | |
| SCHEMBL7468971 | 0.84 | ITGB3 (0.42) | MAPTNR1H2JAK2JAK3PTK2 | |
| SCHEMBL7480246 | 0.83 | ALDH1A1 (0.40) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7473247 | 0.79 | NR1H2 (0.47) | TMEM97SIGMAR1LMNAMAPTNR1H2 | |
| SCHEMBL7481405 | 0.79 | NR1H2 (0.42) | LMNAMAPTNR1H2SMN1; SMN2GPR119 | |
| SCHEMBL7465981 | 0.78 | NR1H2 (0.40) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7419930 | 0.74 | NR1H2 (0.49) | TMEM97SIGMAR1LMNAMAPTNR1H2 | |
| Trifluoroacetic Acid SCHEMBL7475604 | 0.74 | DRD2 (0.34) | TMEM97SIGMAR1SLC6A2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |