Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474738 | 0.96 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL7063202 | 0.79 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL22506569 | 0.76 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL9618235 | 0.76 | HDAC1 (0.56) | ALDH1A1GAALMNAL3MBTL1KDM4E | |
| SCHEMBL11581830 | 0.74 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2GAAMITFALOX12 | |
| SCHEMBL5447985 | 0.73 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL16587380 | 0.73 | NAAA (0.72) | ALDH1A1SMN1; SMN2GAAHTTL3MBTL1 | |
| SCHEMBL21894756 | 0.73 | NAAA (0.72) | ALDH1A1SMN1; SMN2GAAHTTL3MBTL1 | |
| SCHEMBL16587391 | 0.73 | NAAA (0.72) | ALDH1A1SMN1; SMN2GAAHTTL3MBTL1 | |
| SCHEMBL12153832 | 0.73 | HSP90AA1 (0.59) | ALDH1A1SMN1; SMN2GAALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |