Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.65 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.65 |
| ▸ | SYK | P43405 | 3/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | BCR | P11274 | 1/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | DKK1 | O94907 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 7/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198846 | 0.88 | CDK2 (0.61) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12423167 | 0.88 | PIK3CG (0.66) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL14538029 | 0.87 | CDK2 (0.60) | CDK2SRCZAP70SYKPIK3CA | |
| Hydrochloric Acid SCHEMBL2194727 | 0.87 | CDK2 (0.60) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509734 | 0.85 | ABL1 (0.59) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL7468136 | 0.85 | PIK3CG (0.68) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL2194717 | 0.84 | ABL1 (0.58) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL7470877 | 0.84 | CDK2 (0.70) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL14216222 | 0.83 | CDK2 (0.79) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12423706 | 0.82 | PIK3CG (0.68) | CDK2SRCZAP70SYKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |