SCHEMBL7475809

SCHEMBL7475809

CC(OCn1cnc2ccccc21)[Si](C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.53
APAF1 O14727 1/20 0.50
LMNA P02545 6/20 0.49
SMN1; SMN2 Q16637 6/20 0.49
CYP11B1 P15538 5/20 0.47
CYP11B2 P19099 5/20 0.47
TNF P01375 1/20 0.47
HTT P42858 5/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPK1 P28482 3/20 0.45
GAA P10253 1/20 0.45
MAPT P10636 1/20 0.45
AGER Q15109 1/20 0.45
TSHR P16473 2/20 0.44
PKM P14618 1/20 0.44
GGPS1 O95749 1/20 0.44
FDPS P14324 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ALOX15 P16050 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2652538 0.86 TDP1 (0.58) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL7018800 0.83 MAPT (0.35) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL14722865 0.82 TDP1 (0.57) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL7018562 0.81 POLB (0.36) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL7016871 0.80 MAPT (0.41) APAF1SMN1; SMN2CYP11B1CYP11B2TNF
SCHEMBL7019257 0.80 MAPT (0.55) SMN1; SMN2CYP11B1CYP11B2TNFMAPT
SCHEMBL16756562 0.80 TDP1 (0.58) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL2640498 0.77 TDP1 (0.63) TDP1APAF1LMNASMN1; SMN2CYP11B1
SCHEMBL3067924 0.77 TDP1 (0.68) TDP1LMNASMN1; SMN2CYP11B1CYP11B2
SCHEMBL7017087 0.76 AAK1 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882038-B1 SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES AVENTIS PHARMA INC (US) 2002-12-18 EP disclosed
US-6329392-B1 ANTIALLERGENS AVENTIS PHARMACEUTICALS, INC. 2001-12-11 US disclosed
US-6297259-B1 HISTAMINE RECEPTOR ANTAGONISTS AND TACHYKININ RECEPTOR ANTAGONISTS. AVENTIS PHARMACEUTICALS INC. 2001-10-02 US disclosed
US-5998439-A RESPIRATORY SYSTEM DISORDERS Hoescht Marion Roussel, Inc. (US) 1999-12-07 US disclosed
EP-0777666-B1 SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMA INC (US) 1999-03-03 EP disclosed
EP-0882038-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1998-12-09 EP disclosed
WO-1997030990-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed
EP-0777666-A1 NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMACEUTICALS INC. (US) 1997-06-11 EP disclosed
WO-1996006094-A1 NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMACEUTICALS INC. (US) 1996-02-29 WO disclosed