Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | QPCT | Q16769 | 5/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016871 | 0.89 | MAPT (0.41) | MAPTHSD17B10ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7018800 | 0.84 | MAPT (0.35) | MAPTHSD17B10ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7475809 | 0.80 | TDP1 (0.53) | MAPTSMN1; SMN2TNFCYP11B1CYP11B2 | |
| SCHEMBL19848693 | 0.80 | MAPT (0.64) | MAPTHSD17B10ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7017433 | 0.80 | LCK (0.40) | ALDH1A1QPCTQPCTLLCKKDM4E | |
| SCHEMBL30591188 | 0.80 | MAPT (0.56) | MAPTHSD17B10ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7017505 | 0.79 | PKM (0.53) | MAPTALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL7034018 | 0.77 | MAPT (0.64) | MAPTHSD17B10ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7018562 | 0.77 | POLB (0.36) | MAPTSMN1; SMN2QPCTQPCTLPOLB | |
| SCHEMBL2541710 | 0.76 | POLB (0.37) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |