Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315261 | 0.75 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL4320113 | 0.75 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL15986145 | 0.73 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL4307776 | 0.71 | TSHR (0.58) | CHRNB2CHRNA4 | |
| SCHEMBL4315272 | 0.71 | CHRNB2 (0.44) | CHRNB2CHRNA4HTR6 | |
| SCHEMBL2640059 | 0.71 | TSHR (0.47) | CHRNB2CHRNA4CHRNA3CHRNA7HTR1A | |
| SCHEMBL4325786 | 0.70 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL4308694 | 0.70 | CHRNB2 (0.43) | CHRNB2CHRNA4HTR1A | |
| SCHEMBL5335460 | 0.69 | HTR1A (0.71) | CHRNB2CHRNA4HTR6HTR1ASLC6A2 | |
| SCHEMBL4321095 | 0.68 | TSHR (0.46) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178973-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | Pharmacia AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000076984-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | BIOVITRUM AB (SE) | 2000-12-21 | — | — | WO | disclosed |