Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.67 |
| ▸ | DKK1 | O94907 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.57 |
| ▸ | CDK9 | P50750 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469251 | 0.83 | IKBKB (0.52) | IKBKBMAPK8MAPK10CDK1CDK9 | |
| SCHEMBL3519939 | 0.81 | IKBKB (1.00) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL7469678 | 0.80 | SYK (0.56) | CDK2CDK4 | |
| SCHEMBL3519764 | 0.80 | IKBKB (0.97) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL7469285 | 0.80 | IKBKB (0.74) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL7470673 | 0.79 | IKBKB (0.81) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL3521197 | 0.78 | IKBKB (0.71) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL7471251 | 0.78 | JAK2 (0.66) | IKBKBJAK2 | |
| SCHEMBL7471151 | 0.77 | PIK3CA (0.60) | IKBKBCDK2CCNA2 | |
| SCHEMBL3524651 | 0.77 | IKBKB (0.70) | IKBKBDKK1GSK3BMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |