Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.72 |
| ▸ | HTR1B | P28222 | 20/20 | 0.72 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | HTR1F | P30939 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480017 | 0.94 | HTR1D (0.68) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7476719 | 0.89 | HTR1D (0.84) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8899307 | 0.89 | HTR1D (0.71) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7473577 | 0.88 | HTR1D (0.73) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7480812 | 0.88 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7474732 | 0.87 | HTR1D (0.71) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7477505 | 0.84 | HTR1D (0.64) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7477312 | 0.84 | HTR1D (0.83) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8643499 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL4580257 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-1997017338-A1 | SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYLPIPERAZINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-15 | — | — | WO | disclosed |