Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.83 |
| ▸ | HTR1B | P28222 | 20/20 | 0.83 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | HTR1F | P30939 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334690 | 0.91 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8333967 | 0.90 | HTR1D (0.68) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8427579 | 0.88 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL8427576 | 0.88 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL7476611 | 0.88 | HTR1D (0.71) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8474241 | 0.86 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8471754 | 0.86 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8333324 | 0.86 | HTR1D (0.63) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8338429 | 0.86 | HTR1D (0.66) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8143246 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5981529-A | Substituted indolylpropyl-piperazine derivatives as 5-HT1D α agonists | MERCK SHARP & DOHME LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |