Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7650535 | 0.99 | MAPT (0.39) | MAPTUSP2ALDH1A1ALOX15MAPK1 | |
| SCHEMBL7988073 | 0.94 | TP53 (0.43) | MAPTALDH1A1NPSR1DRD2ADRA1A | |
| Hydrochloric Acid SCHEMBL7655743 | 0.93 | TP53 (0.42) | MAPTALDH1A1NPSR1DRD2ADRA1A | |
| SCHEMBL7476712 | 0.91 | DRD2 (0.40) | MAPTMAPK1NPSR1DRD2ADRA1A | |
| Hydrochloric Acid SCHEMBL7481005 | 0.90 | DRD2 (0.39) | MAPTMAPK1NPSR1DRD2ADRA1A | |
| SCHEMBL7422472 | 0.90 | DRD2 (0.43) | DRD2DRD3CYP1A2 | |
| Hydrochloric Acid SCHEMBL7477971 | 0.89 | DRD2 (0.42) | DRD2DRD3CYP1A2 | |
| SCHEMBL7539113 | 0.89 | DRD3 (0.39) | MAPTMAPK1NPSR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7475220 | 0.88 | HTR2A (0.39) | MAPTMAPK1NPSR1DRD2DRD3 | |
| SCHEMBL7650118 | 0.88 | DRD2 (0.43) | DRD2ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221869-B1 | N-aminoalkyldibenzothiophenecarboxamides new dopamine receptor subtype specific ligands | NEUROGEN CORPORATION | 2001-04-24 | — | — | US | claimed |
| EP-0888332-A1 | N-AMINOALKYLDIBENZOTHIOPHENECARBOXAMIDES; DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034889-A1 | N-AMINOALKYLDIBENZOTHIOPHENECARBOXAMIDES; DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1997-09-25 | — | — | WO | disclosed |