Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | HTR7 | P34969 | 17/20 | 0.59 |
| ▸ | HTR1A | P08908 | 8/20 | 0.59 |
| ▸ | DRD5 | P21918 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491730 | 0.95 | HTR7 (0.62) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL23339326 | 0.94 | HTR7 (0.63) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL15396975 | 0.94 | HTR7 (0.63) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL8240109 | 0.90 | HTR7 (0.57) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL19656193 | 0.86 | CHRM2 (0.54) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL6200847 | 0.85 | DRD2 (0.84) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL318584 | 0.83 | HTR7 (0.59) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL10844596 | 0.83 | CHRM2 (0.71) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL12682781 | 0.83 | HTR7 (0.68) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL14649062 | 0.83 | HTR7 (0.56) | DRD2DRD3DRD4HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233943-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | Sugen, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |
| CN-1009197-B | Process for preparing N, 3-disubstituted 2-oxindole-1-carboxamides | PFIZER (US) | 1990-08-15 | — | — | CN | disclosed |