Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.59 |
| ▸ | OXTR | P30559 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11551817 | 0.95 | SMN1; SMN2 (0.81) | SMN1; SMN2NOTUMSIGMAR1HTTALDH1A1 | |
| SCHEMBL9394780 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2NOTUMSIGMAR1ALDH1A1MAPT | |
| SCHEMBL4863174 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2AVPR2AVPR1ANOTUMOXTR | |
| SCHEMBL30456228 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2AVPR2AVPR1ANOTUMOXTR | |
| SCHEMBL30592391 | 0.81 | SMN1; SMN2 (0.74) | SMN1; SMN2NOTUMSIGMAR1HTTALDH1A1 | |
| SCHEMBL330273 | 0.81 | SMN1; SMN2 (0.74) | SMN1; SMN2NOTUMSIGMAR1HTTALDH1A1 | |
| SCHEMBL4865076 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2AVPR2AVPR1ANOTUMOXTR | |
| SCHEMBL5423105 | 0.80 | NOTUM (0.90) | SMN1; SMN2AVPR2AVPR1ANOTUMOXTR | |
| SCHEMBL11326409 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2NOTUMSIGMAR1HTTALDH1A1 | |
| SCHEMBL9559719 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2AVPR2AVPR1ANOTUMOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |
| US-20090171091-A1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2009-07-02 | — | — | US | disclosed |
| EP-2049493-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | Cadila Healthcare Limited (IN) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008059513-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171091-A1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CETP, APOB, HDLBP | SMN1; SMN2 4033/4885AVPR2 3983/4885AVPR1A 3992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.