Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 18/20 | 0.80 |
| ▸ | MMP9 | P14780 | 17/20 | 0.80 |
| ▸ | MMP8 | P22894 | 2/20 | 0.64 |
| ▸ | MMP3 | P08254 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344876 | 0.88 | MMP2 (0.70) | MMP2MMP9MMP8MMP3MMP13 | |
| SCHEMBL8553779 | 0.86 | MMP2 (0.61) | MMP2MMP9MMP8MMP3MMP13 | |
| SCHEMBL7473915 | 0.85 | MMP2 (0.61) | MMP2MMP9MMP8MMP3MMP13 | |
| SCHEMBL8344261 | 0.81 | MMP2 (0.83) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL5924499 | 0.80 | MMP2 (1.00) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL5924337 | 0.80 | MMP2 (1.00) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL5924448 | 0.80 | MMP2 (1.00) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6591431 | 0.79 | MMP2 (0.82) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6593922 | 0.79 | MMP2 (0.61) | MMP2MMP9MMP8MMP3MMP13 | |
| SCHEMBL7472924 | 0.78 | MMP8 (1.00) | MMP2MMP9MMP8MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| CN-1318406-C | New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same | BOEHRINGER MANNHEIM GMBH (DE) | 2007-05-30 | — | — | CN | disclosed |
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | disclosed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |
| CN-1209123-A | New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same | BOEHRINGER MANNHEIM GMBH (DE) | 1999-02-24 | — | — | CN | disclosed |