Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469993 | 1.00 | MAPT (0.46) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL7470002 | 1.00 | MAPT (0.46) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL7474800 | 0.86 | ALDH1A1 (0.60) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL25389335 | 0.82 | PIK3CD (0.49) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL25389339 | 0.82 | PIK3CD (0.49) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL30572685 | 0.82 | PIK3CD (0.49) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL7464017 | 0.82 | MAPT (0.52) | MAPTALDH1A1LMNAGPR119MEN1 | |
| SCHEMBL6734368 | 0.82 | ALDH1A1 (0.52) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL28666823 | 0.82 | MAPT (0.52) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL17958711 | 0.82 | ALDH1A1 (0.52) | MAPTALDH1A1LMNASMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |