Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471594 | 0.89 | NR1H3 (0.47) | MAPTALDH1A1LMNAMAP4K4MEN1 | |
| SCHEMBL7474800 | 0.86 | ALDH1A1 (0.60) | MAPTALDH1A1LMNAMAP4K4MEN1 | |
| SCHEMBL18186400 | 0.82 | ALDH1A1 (0.58) | MAPTALDH1A1LMNAMAP4K4GPR119 | |
| SCHEMBL16824893 | 0.82 | ALDH1A1 (0.58) | MAPTALDH1A1LMNAMAP4K4GPR119 | |
| SCHEMBL7470002 | 0.82 | MAPT (0.46) | MAPTALDH1A1LMNAGPR119MEN1 | |
| SCHEMBL7469993 | 0.82 | MAPT (0.46) | MAPTALDH1A1LMNAGPR119MEN1 | |
| SCHEMBL7476685 | 0.82 | MAPT (0.46) | MAPTALDH1A1LMNAGPR119MEN1 | |
| SCHEMBL22445545 | 0.81 | NCF1 (0.53) | MAPTMAP4K4GPR119HDAC1MEN1 | |
| SCHEMBL22441524 | 0.81 | NCF1 (0.53) | MAPTMAP4K4GPR119HDAC1MEN1 | |
| SCHEMBL22441526 | 0.81 | NCF1 (0.53) | MAPTMAP4K4GPR119HDAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |