Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SDCBP | O00560 | 2/20 | 0.47 |
| ▸ | SDC2 | P34741 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17131545 | 0.84 | HPGD (0.49) | HPGDKDM4EMTNR1AMTNR1BFKBP1A | |
| SCHEMBL1496584 | 0.81 | HPGD (0.47) | HPGDSDCBPSDC2TSHRCYP2C19 | |
| SCHEMBL11271675 | 0.78 | MTNR1A (0.71) | HPGDSDCBPSDC2TSHRCYP2C19 | |
| SCHEMBL16485029 | 0.78 | PPARD (0.43) | CYP2C19CYP1A2CYP2D6MTNR1AMTNR1B | |
| SCHEMBL11271948 | 0.77 | HPGD (0.46) | HPGDSDCBPSDC2TSHRCYP2C19 | |
| SCHEMBL11271943 | 0.77 | HPGD (0.46) | HPGDSDCBPSDC2TSHRCYP2C19 | |
| SCHEMBL3972663 | 0.77 | MC4R (0.46) | HPGDSDCBPSDC2KMT2AALDH1A1 | |
| SCHEMBL8258989 | 0.77 | HPGD (0.50) | HPGDSDCBPSDC2TSHRCYP2C19 | |
| SCHEMBL13235901 | 0.76 | SLC6A2 (0.53) | CYP2C19CYP1A2CYP2D6BRD4CYP2C9 | |
| SCHEMBL11242882 | 0.76 | SLC6A2 (0.53) | CYP2C19CYP1A2CYP2D6BRD4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |