SCHEMBL7477209

SCHEMBL7477209

CCc1nc2c([nH]1)c(=S)n(CC)c(=O)n2CC(C)CC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 2/20 0.41
SIRT3 Q9NTG7 2/20 0.41
SIRT5 Q9NXA8 2/20 0.41
PDE1A P54750 2/20 0.39
PDE1B Q01064 2/20 0.39
PDE1C Q14123 2/20 0.39
MEN1 O00255 1/20 0.39
PDE5A O76074 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.37
ADORA2A P29274 3/20 0.35
ADORA2B P29275 3/20 0.35
ADORA1 P30542 3/20 0.35
ADORA3 P0DMS8 1/20 0.35
PDE2A O00408 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7468034 0.86 SIRT1 (0.48) SIRT1SIRT3SIRT5CYP1A2CYP3A4
SCHEMBL7414849 0.81 ADORA1 (0.55) MEN1CYP1A2TSHRKMT2AADORA2A
SCHEMBL10963761 0.81 PDE5A (0.60) PDE1APDE1BPDE1CMEN1PDE5A
SCHEMBL9645048 0.81 CYP3A4 (0.35) SIRT1SIRT3SIRT5PDE1APDE1B
SCHEMBL9645631 0.77 ADORA2A (0.40) PDE1APDE1BPDE1CMEN1PDE5A
SCHEMBL7201941 0.77 SIRT1 (0.62) SIRT1SIRT3SIRT5PDE1APDE1B
SCHEMBL7414170 0.76 ADORA1 (0.52) SIRT1SIRT3SIRT5ADORA2AADORA2B
SCHEMBL7475458 0.74 PDE1A (0.59) PDE1APDE1BPDE1CMEN1PDE5A
SCHEMBL7469763 0.74 ADORA1 (0.40) SIRT1SIRT3SIRT5CYP3A4CYP2C19
SCHEMBL7424268 0.74 SIRT1 (0.50) SIRT1SIRT3SIRT5CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6268373-B1 ENZYME INHIBITORS EURO-CELTIQUE S.A. (LU) 2001-07-31 US claimed
EP-0799040-A4 TRISUBSTITUTED THIOXANTHINES EURO CELTIQUE SA (LU) 1998-04-01 EP claimed
EP-0799040-A1 TRISUBSTITUTED THIOXANTHINES Euroceltique S.A. (LU) 1997-10-08 EP claimed
WO-1996018400-A1 TRISUBSTITUTED THIOXANTHINES EURO-CELTIQUE, S.A. (LU) 1996-06-20 WO claimed
US-6268373-B1 ENZYME INHIBITORS EURO-CELTIQUE S.A. (LU) 2001-07-31 US disclosed
US-6025361-A EFFECTIVE PDE IV INHIBITORS, ASTHMA EURO-CELTIQUE, S.A. (LU) 2000-02-15 US disclosed
US-5977119-A Trisubstituted thioxanthines EURO-CELTIQUE, S.A. (LU) 1999-11-02 US disclosed
EP-0799040-A4 TRISUBSTITUTED THIOXANTHINES EURO CELTIQUE SA (LU) 1998-04-01 EP disclosed
EP-0799040-A1 TRISUBSTITUTED THIOXANTHINES Euroceltique S.A. (LU) 1997-10-08 EP disclosed
WO-1996018400-A1 TRISUBSTITUTED THIOXANTHINES EURO-CELTIQUE, S.A. (LU) 1996-06-20 WO disclosed