Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385272 | 0.83 | ALDH1A1 (0.67) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL30177244 | 0.83 | ALDH1A1 (0.67) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL27634125 | 0.82 | ALDH1A1 (0.60) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL11054997 | 0.81 | ALDH1A1 (0.64) | HPGDALDH1A1TDP1TSHRPOLB | |
| Hydrochloric Acid SCHEMBL1373195 | 0.81 | ALDH1A1 (0.64) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL11055034 | 0.81 | ALDH1A1 (0.64) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL1523175 | 0.80 | TSHR (0.53) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL28476326 | 0.80 | ALDH1A1 (0.62) | HPGDALDH1A1TDP1TSHRPOLB | |
| SCHEMBL28205348 | 0.80 | TSHR (0.61) | HPGDALDH1A1TSHRPOLBHTT | |
| SCHEMBL2600784 | 0.79 | TSHR (0.56) | HPGDALDH1A1TDP1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |