Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.63 |
| ▸ | HTR1B | P28222 | 13/20 | 0.63 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | MPO | P05164 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477312 | 0.86 | HTR1D (0.83) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8333967 | 0.85 | HTR1D (0.68) | HTR1DHTR1BHTR1AMPOHTR2A | |
| SCHEMBL8331600 | 0.84 | HTR1D (0.60) | HTR1DHTR1BHTR1AMPOHTR2A | |
| SCHEMBL8336283 | 0.80 | HTR1D (0.70) | HTR1DHTR1BHTR1A | |
| SCHEMBL8334690 | 0.77 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8332389 | 0.76 | HTR1D (0.81) | HTR1DHTR1B | |
| SCHEMBL8332061 | 0.75 | HTR1D (0.70) | HTR1DHTR1BHTR1AMPOHTR2A | |
| SCHEMBL8427576 | 0.75 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8427579 | 0.75 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7476611 | 0.75 | HTR1D (0.71) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981529-A | Substituted indolylpropyl-piperazine derivatives as 5-HT1D α agonists | MERCK SHARP & DOHME LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| EP-0854714-A1 | SUBSTITUTED INDOLYLPROPYL-PIPERAZINE DERIVATIVES AS 5-HT 1DALPHA? AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997011695-A1 | SUBSTITUTED INDOLYLPROPYL-PIPERAZINE DERIVATIVES AS 5-HT1DALPHA AGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-04-03 | — | — | WO | disclosed |