Puromycin

Puromycin

SCHEMBL747760

COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1.Cc1ccc2c(c1O)NC(O)C1CC(/C=C/C(N)=O)=CN1C2=O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NPEPPS P55786 14/20 0.64
ANPEP P15144 10/20 0.64
SMN1; SMN2 Q16637 3/20 0.64
TP53 P04637 2/20 0.64
CYP3A4 P08684 2/20 0.64
LMNA P02545 1/20 0.64
HIF1A Q16665 1/20 0.64
HTT P42858 1/20 0.64
NPC1 O15118 1/20 0.64
RAB9A P51151 1/20 0.64
PAX8 Q06710 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Puromycin SCHEMBL14583945 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL3042415 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20815730 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20393806 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22409382 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL24206459 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22348910 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21306559 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21481061 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL14583797 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11945874-B2 Anti-human CD52 immunoglobulins GENZYME CORPORATION (US) 2024-04-02 US disclosed
US-20230295338-A1 A NOVEL ANTIBODY BINDING SPECIFICALLY TO HUMAN CEACAM1/3/5 AND USE THEREOF YMMUNOBIO AG (CH) 2023-09-21 US disclosed
EP-4149522-A1 A NOVEL ANTIBODY BINDING SPECIFICALLY TO HUMAN CEACAM1/3/5 AND USE THEREOF Ymmunobio AG (CH) 2023-03-22 EP disclosed
US-20220010024-A1 Anti-Human CD52 Immunoglobulins GENZYME CORPORATION (US) 2022-01-13 US disclosed
WO-2021228746-A1 A NOVEL ANTIBODY BINDING SPECIFICALLY TO HUMAN CEACAM1/3/5 AND USE THEREOF LEUKOCOM GMBH (DE) 2021-11-18 WO disclosed
EP-3909601-A1 A NOVEL ANTIBODY BINDING SPECIFICALLY TO HUMAN CEACAM1/3/5 AND USE THEREOF LeukoCom GmbH (DE) 2021-11-17 EP disclosed
EP-3683317-A2 ANTI-HUMAN CD52 IMMUNOGLOBULINS Genzyme Corporation (US) 2020-07-22 EP disclosed
US-20200040091-A1 Anti-Human CD52 Immunoglobulins GENZYME CORPORATION (US) 2020-02-06 US disclosed
CN-110016081-A Anti-human cd 52 immunoglobulins 基酶有限公司 2019-07-16 CN disclosed
EP-3058955-B1 ANTIBODIES THAT BIND OV064 AND METHODS OF USE THEREFOR MILLENNIUM PHARM INC (US) 2019-05-29 EP disclosed
EP-1948691-A1 HUMANIZED IMMUNOGLOBULIN REACTIVE WITH a4ß7INTEGRIN MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-07-30 EP disclosed
EP-1868647-A2 ANTIBODIES THAT BIND OV064 AND METHODS OF USE THEREFOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-12-26 EP disclosed
WO-2007085815-A2 LIGANDS THAT BIND IL-4 AND/OR IL-13 DOMANTIS LIMITED (GB) 2007-08-02 WO disclosed
WO-2007080392-A2 LIGANDS THAT HAVE BINDING SPECIFICITY FOR VEGF AND/OR EGFR AND METHODS OF USE THEREFOR DOMANTIS LIMITED (GB) 2007-07-19 WO disclosed
WO-2007066109-A1 BISPECIFIC LIGANDS WITH BINDING SPECIFICITY TO CELL SURFACE TARGETS AND METHODS OF USE THEREFOR DOMANTIS LIMITED (GB) 2007-06-14 WO disclosed
WO-2007066106-A1 LIGANDS THAT HAVE BINDING SPECIFICITY FOR EGFR AND/OR VEGF AND METHODS OF USE THEREFOR DOMANTIS LIMITED (GB) 2007-06-14 WO disclosed
WO-2007061679-A1 HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-05-31 WO disclosed
US-20070122404-A1 Humanized immunoglobulin reactive with alpha4beta7 integrin MILLENNIUM PHARMACEUTICALS, INC. 2007-05-31 US disclosed
US-20070003549-A1 Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor DOMANTIS LIMITED (GB) 2007-01-04 US disclosed
WO-2006104677-A2 ANTIBODIES THAT BIND OV064 AND METHODS OF USE THEREFOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2006-10-05 WO disclosed