Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486082 | 0.91 | HTR6 (0.49) | HTR6SLC6A4KMT2AHRH1CCR3 | |
| SCHEMBL7485121 | 0.85 | HTR6 (0.54) | HTR6SLC6A4 | |
| SCHEMBL7483235 | 0.84 | HTR6 (0.53) | HTR6SLC6A4 | |
| SCHEMBL7488142 | 0.84 | HTR6 (0.50) | HTR6SLC6A4 | |
| SCHEMBL7485600 | 0.81 | HTR6 (0.55) | HTR6SLC6A4 | |
| SCHEMBL7485143 | 0.79 | HTR6 (0.52) | HTR6 | |
| SCHEMBL4670820 | 0.76 | HTR6 (0.55) | HTR6 | |
| SCHEMBL4674840 | 0.76 | HTR6 (0.55) | HTR6SLC6A4 | |
| SCHEMBL2063673 | 0.76 | HTR6 (0.55) | HTR6 | |
| SCHEMBL7486142 | 0.76 | HTR6 (0.66) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | claimed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | claimed |
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |