Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485143 | 0.86 | HTR6 (0.52) | HTR6 | |
| SCHEMBL7477820 | 0.86 | HTR6 (0.68) | HTR6ELANE | |
| SCHEMBL7485600 | 0.85 | HTR6 (0.55) | HTR6SLC6A4 | |
| SCHEMBL7490788 | 0.84 | HTR6 (0.56) | HTR6SLC6A4 | |
| SCHEMBL7490243 | 0.84 | HTR6 (0.56) | HTR6SLC6A4 | |
| SCHEMBL7477833 | 0.84 | HTR6 (0.48) | HTR6SLC6A4 | |
| SCHEMBL2063673 | 0.78 | HTR6 (0.55) | HTR6ELANE | |
| SCHEMBL7485451 | 0.75 | HTR6 (0.57) | HTR6SLC6A4 | |
| SCHEMBL4674653 | 0.75 | HTR6 (0.58) | HTR6 | |
| SCHEMBL7486082 | 0.75 | HTR6 (0.49) | HTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | claimed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | claimed |
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |