Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.74 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.74 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.67 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.61 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756369 | 0.93 | MRGPRX4 (0.81) | MRGPRX4NR4A2NR1H4TP53PKM | |
| SCHEMBL18625354 | 0.91 | NR4A2 (0.77) | MRGPRX4NR4A2NR4A1NR4A3NR1H4 | |
| SCHEMBL16320242 | 0.88 | NR4A2 (0.71) | MRGPRX4NR4A2NR4A1NR4A3MCL1 | |
| SCHEMBL17952637 | 0.88 | NR4A2 (0.71) | MRGPRX4NR4A2NR4A1NR4A3MCL1 | |
| SCHEMBL4442592 | 0.88 | MRGPRX4 (0.70) | MRGPRX4NR4A2NR1H4TP53PKM | |
| SCHEMBL27754433 | 0.87 | NR4A2 (0.69) | MRGPRX4NR4A2NR4A1NR4A3NR1H4 | |
| SCHEMBL4442371 | 0.86 | MRGPRX4 (0.71) | MRGPRX4NR4A2NR1H4TP53PKM | |
| SCHEMBL4949143 | 0.86 | NR4A2 (0.90) | NR4A2NR4A1NR4A3MCL1SMN1; SMN2 | |
| SCHEMBL10459767 | 0.85 | MRGPRX4 (0.79) | MRGPRX4NR4A2NR4A1NR4A3NR1H4 | |
| SCHEMBL3565625 | 0.85 | MRGPRX4 (1.00) | MRGPRX4NR4A2NR1H4TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | disclosed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |
| US-6110924-A | MATRIX METALLOPROTEASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-29 | — | — | US | disclosed |