Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.79 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.74 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.70 |
| ▸ | RXRA | P19793 | 3/20 | 0.69 |
| ▸ | RXRB | P28702 | 3/20 | 0.69 |
| ▸ | PTGES | O14684 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.67 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.64 |
| ▸ | RXRG | P48443 | 1/20 | 0.63 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18625354 | 0.91 | NR4A2 (0.77) | MRGPRX4NR4A2SRD5A2RXRARXRB | |
| SCHEMBL27734092 | 0.90 | MRGPRX4 (0.73) | MRGPRX4NR4A2SRD5A2RXRARXRB | |
| SCHEMBL3565625 | 0.88 | MRGPRX4 (1.00) | MRGPRX4NR4A2SMN1; SMN2NR1H4 | |
| SCHEMBL16321477 | 0.88 | MEN1 (0.73) | MRGPRX4NR4A2SRD5A2RXRARXRB | |
| SCHEMBL3678773 | 0.86 | MRGPRX4 (0.64) | MRGPRX4NR4A2SRD5A2RXRARXRB | |
| SCHEMBL5944125 | 0.86 | SMPD1 (0.79) | MRGPRX4NR4A2NR1H4SMPD1HDAC4 | |
| SCHEMBL4949143 | 0.86 | NR4A2 (0.90) | NR4A2SRD5A2RXRARXRBPTGES | |
| SCHEMBL2137838 | 0.86 | MRGPRX4 (0.69) | MRGPRX4NR4A2ALOX5HDAC4MAOB | |
| SCHEMBL7477872 | 0.85 | MRGPRX4 (0.74) | MRGPRX4NR4A2SRD5A2SMN1; SMN2NR4A1 | |
| SCHEMBL1123461 | 0.85 | NR4A2 (0.81) | MRGPRX4NR4A2SRD5A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2020-09-24 | — | — | US | disclosed |
| US-4916145-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1990-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | MRGPRX4 85/4885NR4A2 4745/4885SRD5A2 4796/4885 |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | MAGI3, PYM1, MAG | MRGPRX4 85/4885NR4A2 4745/4885SRD5A2 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.