Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 6/20 | 0.38 |
| ▸ | HRH1 | P35367 | 6/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480678 | 0.92 | MMP2 (0.38) | KCNA5MMP2MMP3CHRNA7HRH2 | |
| SCHEMBL7256965 | 0.89 | MMP2 (0.36) | KCNA5MMP2MMP3CHRNA7HRH2 | |
| SCHEMBL6738151 | 0.85 | KCNA5 (0.47) | KCNA5CHRNA7HRH2HRH1HRH3 | |
| SCHEMBL7474774 | 0.83 | KCNA5 (0.42) | KCNA5MMP2MMP3HRH2HRH1 | |
| SCHEMBL7481488 | 0.81 | HRH2 (0.37) | KCNA5MMP2MMP3HRH2HRH1 | |
| SCHEMBL6738742 | 0.81 | HRH2 (0.45) | KCNA5CHRNA7HRH2HRH1HRH3 | |
| SCHEMBL6740378 | 0.80 | HRH3 (0.42) | KCNA5CHRNA7HRH2HRH1HRH3 | |
| SCHEMBL6737930 | 0.78 | CHRNA7 (0.36) | MMP2CHRNA7HRH2HRH1HRH3 | |
| SCHEMBL6739387 | 0.77 | KCNH2 (0.50) | ALDH1A1MAPT | |
| SCHEMBL6734797 | 0.77 | KCNH2 (0.50) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |