Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | HRH2 | P25021 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477901 | 0.83 | KCNA5 (0.39) | KCNA5HRH3HRH1HRH2MMP2 | |
| SCHEMBL7481488 | 0.79 | HRH2 (0.37) | KCNA5HRH3MEN1HRH1HRH2 | |
| SCHEMBL6741147 | 0.76 | DPP4 (0.36) | KCNA5HRH3MEN1SCN9ASLC6A4 | |
| SCHEMBL6738989 | 0.76 | DPP4 (0.41) | HRH3MEN1DPP4DPP8KCNH2 | |
| SCHEMBL6741138 | 0.75 | KCNH2 (0.40) | HRH3MEN1DPP4DPP8KCNH2 | |
| SCHEMBL7480678 | 0.75 | MMP2 (0.38) | KCNA5HRH3HRH1HRH2MMP2 | |
| SCHEMBL7256965 | 0.72 | MMP2 (0.36) | KCNA5HRH3HRH1HRH2MMP2 | |
| SCHEMBL6742548 | 0.70 | GPR119 (0.37) | HRH3MEN1DPP4DPP8KCNH2 | |
| SCHEMBL6622261 | 0.70 | KCNA5 (0.43) | KCNA5HRH3MEN1HRH1HRH2 | |
| SCHEMBL6742543 | 0.70 | KCNH2 (0.39) | MEN1HRH1HRH2DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |