Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.50 |
| ▸ | CTSL | P07711 | 12/20 | 0.50 |
| ▸ | CTSS | P25774 | 8/20 | 0.50 |
| ▸ | CTSB | P07858 | 6/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686330 | 0.86 | CTSK (0.60) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7039978 | 0.86 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7039976 | 0.86 | CTSK (0.44) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7477924 | 0.85 | CTSK (0.49) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5092928 | 0.84 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6630415 | 0.83 | SMN1; SMN2 (0.39) | CTSKCTSLCTSSCTSBSMN1; SMN2 | |
| SCHEMBL6625612 | 0.81 | TP53 (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7432035 | 0.80 | ALDH1A1 (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5092922 | 0.80 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7431356 | 0.80 | KMT2A (0.46) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |