SCHEMBL7477933

SCHEMBL7477933

NC(=O)N1C(=O)NC(=O)C(c2ccccc2)C1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.39
ALDH1A1 P00352 4/20 0.37
MAPK1 P28482 3/20 0.37
MAPT P10636 3/20 0.37
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
LMNA P02545 2/20 0.36
TP53 P04637 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
HTR2B P41595 1/20 0.36
TSHR P16473 1/20 0.36
SCN4A P35499 1/20 0.36
SCN5A Q14524 1/20 0.36
SCN9A Q15858 1/20 0.36
USP2 O75604 1/20 0.36
BCHE P06276 1/20 0.35
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6401309 0.75 LMNA (0.50) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL6399674 0.75 LMNA (0.50) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL15460833 0.74 ALDH1A1 (0.44) CA2ALDH1A1MAPK1MAPTKMT2A
SCHEMBL15978121 0.72 LMNA (0.40) CA2ALDH1A1MAPK1MAPTKMT2A
SCHEMBL1639996 0.72 ALDH1A1 (0.42) ALDH1A1MAPTKMT2AMEN1POLB
SCHEMBL9357957 0.71 LMNA (0.40) CA2ALDH1A1MAPK1MAPTKMT2A
SCHEMBL1639968 0.70 LMNA (0.57) ALDH1A1MAPK1MAPTKMT2AMEN1
SCHEMBL15458735 0.70 ALDH1A1 (0.41) CA2ALDH1A1MAPK1MAPTKMT2A
SCHEMBL66999 0.69 MEN1 (0.51) ALDH1A1KMT2AMEN1POLBGAA
SCHEMBL1263711 0.68 MEN1 (0.50) ALDH1A1KMT2AMEN1POLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP claimed
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP disclosed