Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478263 | 0.81 | MEN1 (0.33) | NPSR1 | |
| SCHEMBL6583292 | 0.74 | KCNH2 (0.42) | DHODHPARP1 | |
| SCHEMBL6585161 | 0.72 | PARP1 (0.46) | DHODHPARP1 | |
| SCHEMBL6583248 | 0.71 | DHODH (0.34) | DHODHPARP1 | |
| SCHEMBL7333705 | 0.71 | PARP1 (0.62) | DHODHPARP1 | |
| SCHEMBL7421982 | 0.71 | PARP1 (0.47) | DHODHPARP1 | |
| SCHEMBL29893736 | 0.70 | DHODH (0.38) | DHODHPARP1CYP2C9CYP2C19NPSR1 | |
| SCHEMBL31177973 | 0.70 | DHODH (0.38) | DHODHPARP1CYP2C9CYP2C19NPSR1 | |
| SCHEMBL30938989 | 0.68 | DYRK1A (0.40) | DHODHPARP1 | |
| SCHEMBL8953009 | 0.68 | PARP1 (0.47) | DHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |