Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 9/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583295 | 0.81 | KCNH2 (0.35) | KCNH2MAPTNR3C2 | |
| SCHEMBL6585161 | 0.76 | PARP1 (0.46) | DHODHPARP1AR | |
| SCHEMBL6583248 | 0.75 | DHODH (0.34) | DHODHPARP1 | |
| SCHEMBL7478259 | 0.74 | DHODH (0.38) | DHODHPARP1 | |
| SCHEMBL7333705 | 0.72 | PARP1 (0.62) | DHODHPARP1 | |
| SCHEMBL6581353 | 0.71 | LCK (0.46) | KCNH2MEN1KMT2A | |
| SCHEMBL27525212 | 0.71 | NR3C2 (0.42) | MAPTNR3C2MEN1KMT2A | |
| SCHEMBL12999439 | 0.68 | KMT2A (0.42) | DHODHMAPTPARP1MEN1KMT2A | |
| SCHEMBL6142336 | 0.68 | SMN1; SMN2 (0.38) | KCNH2PARP1NR3C2 | |
| SCHEMBL2424903 | 0.67 | SMN1; SMN2 (0.42) | MAPTNR3C2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |