Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583253 | 0.85 | GABRA1 (0.30) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6583292 | 0.75 | KCNH2 (0.42) | DHODHPARP1 | |
| SCHEMBL6585161 | 0.73 | PARP1 (0.46) | DHODHPARP1GABRA1GABRG2GABRB3 | |
| SCHEMBL7478259 | 0.71 | DHODH (0.38) | DHODHPARP1 | |
| SCHEMBL7333705 | 0.70 | PARP1 (0.62) | DHODHPARP1 | |
| SCHEMBL6954591 | 0.65 | GABRA1 (0.30) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6954595 | 0.65 | GABRA1 (0.30) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL8132021 | 0.63 | DHODH (0.54) | DHODHPARP1 | |
| SCHEMBL5822166 | 0.62 | ALDH1A1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6585164 | 0.62 | HSP90AA1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |