Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | RORC | P51449 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636075 | 0.97 | SLC6A4 (0.53) | SLC6A4HTR1ARORCDRD2CYP11B2 | |
| SCHEMBL3886520 | 0.90 | SLC6A4 (0.51) | SLC6A4HTR1ARORCDRD2CYP11B2 | |
| SCHEMBL6639237 | 0.88 | SLC6A4 (0.43) | SLC6A4HTR1ARORCDRD2CYP11B2 | |
| SCHEMBL6637096 | 0.85 | HTR1A (0.53) | SLC6A4HTR1ARORCDRD2CNR1 | |
| SCHEMBL6639951 | 0.82 | HTR1A (0.52) | SLC6A4HTR1ARORCCYP11B2CNR1 | |
| SCHEMBL6635822 | 0.82 | SLC6A4 (0.56) | SLC6A4HTR1ARORCCYP11B2CNR1 | |
| SCHEMBL7972314 | 0.81 | SLC6A4 (0.44) | SLC6A4HTR1ARORCCYP11B2CNR1 | |
| SCHEMBL6636952 | 0.78 | DRD2 (0.64) | SLC6A4HTR1ARORCDRD2 | |
| SCHEMBL6637786 | 0.77 | SLC6A4 (0.50) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6636890 | 0.76 | SLC6A4 (0.52) | SLC6A4HTR1ARORCDRD2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |