Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478525 | 0.70 | ALDH1A1 (0.33) | LMNAKDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL7478512 | 0.70 | ALDH1A1 (0.33) | LMNAKDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL7478131 | 0.69 | ALDH1A1 (0.32) | KMT2ALMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL7478128 | 0.69 | ALDH1A1 (0.32) | KMT2ALMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL170291 | 0.63 | ESR1 (0.42) | KMT2ALMNASMN1; SMN2TSHRHPGD | |
| SCHEMBL7630371 | 0.63 | ALDH1A1 (0.35) | KMT2ALMNAKDM4ETSHRHPGD | |
| SCHEMBL5932891 | 0.63 | — | — | |
| SCHEMBL5932881 | 0.63 | — | — | |
| SCHEMBL12766691 | 0.62 | KDM4E (0.36) | KMT2AKDM4EMAPT | |
| SCHEMBL7479670 | 0.62 | MEN1 (0.36) | KMT2ALMNAKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |