Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487012 | 0.92 | KDM4E (0.37) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL7475018 | 0.85 | KDM4E (0.32) | ALDH1A1KDM4ELMNAMAPTNPSR1 | |
| SCHEMBL7474346 | 0.81 | NPC1 (0.32) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL7477896 | 0.81 | MEN1 (0.33) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL7478235 | 0.80 | ADORA2B (0.31) | MEN1KMT2A | |
| SCHEMBL7482378 | 0.79 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL7478089 | 0.78 | KDM4E (0.32) | ALDH1A1KDM4EHPGDLMNAMAPT | |
| SCHEMBL7476327 | 0.78 | ALDH1A1 (0.30) | ALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL7478519 | 0.78 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL7480607 | 0.78 | ALDH1A1 (0.31) | ALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |