SCHEMBL7478629

SCHEMBL7478629

COC1(c2cc(F)cc(OCc3ccc(N(C)C(=O)C(C)(C)C)cc3)c2)CCOCC1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 20/20 0.59
PTGS1 P23219 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7472202 0.89 ALOX5 (0.58) ALOX5
SCHEMBL7470417 0.89 ALOX5 (0.58) ALOX5PTGS1
SCHEMBL7479661 0.89 ALOX5 (0.61) ALOX5PTGS1
SCHEMBL7535396 0.89 ALOX5 (0.61) ALOX5PTGS1
SCHEMBL7474009 0.87 ALOX5 (0.59) ALOX5PTGS1
SCHEMBL7534448 0.87 ALOX5 (0.59) ALOX5
SCHEMBL7476166 0.87 ALOX5 (0.55) ALOX5
SCHEMBL7472266 0.86 ALOX5 (0.58) ALOX5
SCHEMBL7475887 0.86 ALOX5 (0.58) ALOX5
SCHEMBL7477954 0.86 ALOX5 (0.58) ALOX5PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250332-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION Abbott Laboratories (US) 2002-10-23 EP claimed
WO-2001044223-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION ABBOTT LABORATORIES (US) 2001-06-21 WO claimed