Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22999808 | 0.84 | PTGER4 (0.58) | SMN1; SMN2GAAPTGER4MAPTALDH1A1 | |
| SCHEMBL13516183 | 0.83 | KDM4E (0.46) | SMN1; SMN2GAAPTGER4MAPTALDH1A1 | |
| SCHEMBL28180588 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2GAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL27275816 | 0.80 | GAA (0.51) | SMN1; SMN2GAAPTGER4MAPTALDH1A1 | |
| SCHEMBL7405207 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2GAAPTGER4MAPTALDH1A1 | |
| SCHEMBL12867382 | 0.78 | GAA (0.58) | SMN1; SMN2GAAPTGER4MAPTALDH1A1 | |
| SCHEMBL7426825 | 0.77 | HSD17B10 (0.63) | SMN1; SMN2GAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL19211610 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL7414257 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL5627215 | 0.75 | GAA (0.56) | SMN1; SMN2GAAMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |