Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.43 |
| ▸ | YAP1 | P46937 | 3/20 | 0.42 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.39 |
| ▸ | CASP3 | P42574 | 4/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | CASP6 | P55212 | 4/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473763 | 1.00 | ITGB1 (0.44) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6474215 | 0.93 | ITGB1 (0.46) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6474104 | 0.91 | KMT2A (0.45) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6478996 | 0.91 | CACNA1B (0.47) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6481231 | 0.90 | ITGB1 (0.46) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6479143 | 0.90 | ITGB1 (0.45) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6480951 | 0.89 | MAPK1 (0.47) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6480791 | 0.87 | YAP1 (0.46) | ITGB1ITGA4ITGB7YAP1GPR34 | |
| SCHEMBL6474590 | 0.87 | ITGB1 (0.49) | ITGB1ITGA4ITGB7CACNA1BYAP1 | |
| SCHEMBL6481324 | 0.86 | MAPK1 (0.44) | ITGB1ITGA4ITGB7CACNA1BYAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |